Hemin–G-quadruplex-crosslinked poly-N-isopropylacrylamide hydrogel: a catalytic matrix for the deposition of conductive polyaniline† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c5sc02203g
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چکیده
A G-rich nucleic acid-tethered acrylamide/N-isopropylacrylamide (NIPAM) copolymer is prepared. The nucleic acid-modified pNIPAM chains assemble, in the presence of K ions, into a stimuli-responsive G-quadruplex-crosslinked pNIPAM hydrogel undergoing cyclic and reversible solution/hydrogel/solid transitions. Addition of kryptofix [2.2.2], CP, to the K-stabilized G-quadruplex-crosslinked hydrogel eliminates the K ions from the crosslinking units, resulting in the transition of the hydrogel into a pNIPAM solution. In turn, heating the pNIPAM hydrogel from 25 C to 40 C results in the transition of the hydrogel to the solid state, and cooling the solid to 25 C restores the hydrogel state. Incorporation of hemin into the G-quadruplex-crosslinked hydrogel results in a catalytic hydrogel that catalyzes the oxidation of aniline by H2O2 to form polyaniline. The polyaniline/pNIPAM hydrogel hybrid doped with 2 M HCl forms an emeraldine salt, which exhibits an electrical conductivity of 9 10 4 [cm U] .
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Figure 1. Evolution of the shear elastic modulus of the stoichiometric 8-H:8-AA hydrogel. Fitting these data to Equation 1, the equilibrium modulus, G eq , is 30 kPa unswollen. After swelling, this value declines to ca. 10 kPa, which was previously reported. The data are the open squares and the fit is the solid line.
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